The introduction of 7G Network technology promised miraculous technological advancements; however, the aftermath of its launch plunged Japan into chaos. From drastic changes to the terrain to bizarre mutations among people, the way of life is overwritten with new rules. The town of Agano is one of the few remaining settlements, and its citizens aged 21 and above have transformed into animals. Shizuru Chikura, a high school student from Agano, is desperately searching for her friend, Youka Nakatomi. Coming across a picture in a newspaper placing Youka in Ikebukuro, Shizuru starts packing for a trip. But with public transportation effectively shut down, her options are limited. Fortunately, Tairo Zenjirou, a senile old conductor and the only human adult in town, comes to the rescue when he teaches her how to operate an abandoned train. With her destination set, Shizuru ventures off on a journey to find her missing friend. On the day of departure, however, her other classmates—Nadeshiko Hoshi, Reimi Kuga, and Akira Shinonome—decide to tag along at the last minute as they embark on this one-track adventure that might expose them to dangers far surpassing anything they have encountered in Agano.

Sousuke Kaburaya, an impoverished detective, meets Sara, a princess from another world with magical powers. They start living together, and Sara quickly adjusts her life to modern Japan.

In the Kingdom of Yamauchi, people have the ability to transform into three-legged crows known as yatagarasu. While the men plot over daily governance, women compete for the hand of Wakamiya, the crown prince who was selected as the Kinu, the servant to the Mountain God. Four young women arrive at the court to join the competition, including one named Asebi. While the kind and innocent Asebi sticks out like a sore thumb compared to the other women, the crown prince has to fight for his place in the clan. Despite being born both to a concubine and as a second son, the royal priests still chose Wakamiya to be the Kinu over his older brother. This decision created a rift between the siblings while enraging Wakamiya's stepmother in the process. When Yukiya, one of the teenage sons of the village chief, is sent to the palace to become Wakamiya's new attendant, the prince is not pleased in the slightest. However, Yukiya's presence at the imperial courts is no mere coincidence.

Haruka Kiyomine and Kei Kaname were once recognized as the most formidable pitcher-catcher duo in middle school baseball. Known as the "General," Kaname paired his expert strategies with Kiyomine's explosive pitches, crushing the dreams of many starry-eyed players who hoped to one day make it to the big leagues. High school freshman Tarou Yamada is one such former player. Having given up on competing, he enrolls in Kotesashi High School—a completely average public school with no baseball team to speak of—where he discovers that his new classmates are the legendary pair who once destroyed his dreams. Adding to this shocking revelation, he learns that amnesia has reduced the once level-headed General to a vulgar class clown. Having lost all interest in baseball, Kaname dragged a disappointed Kiyomine to Kotesashi simply because the school was close to where they live. As Kotesashi forms a fledgling baseball club, Yamada meets other players he once admired who also left baseball behind. While they might be unwilling now, Yamada believes that if he can convince such talented athletes to start playing again, it might be possible to achieve their dreams and win the national championship—as long as they can put up with Kaname's incessant joking.