Continuing where the first season left off, the sudden increase of Thanatos with the disappearance of the Aube Hunters has now left Arcadia in ruin. Desperation reigns high as the Religious Organization fights to battle the Thanatos. Six months had already past since Hidamari mansion burned to ashes, the Aube Hunters, once hailed as heroes, is now blamed for the appearance of Thanatos. Nevertheless, hope still exists for the reappearance of the Queen's Egg one day, who will become the savior of Arcadia. Unknown to many however, the Aube Hunters have actually been silently waiting for the awakening of Angelique, who has been asleep the entire time.

Nana Komatsu is a helpless, naïve 20-year-old who easily falls in love and becomes dependent and clingy to those around her. Even though she nurses ambitious dreams of removing herself from her provincial roots and finding her true calling, she ends up traveling to Tokyo with the humble reason of chasing her current boyfriend Shouji Endo. Nana Osaki, on the other hand, is a proud, enigmatic punk rock vocalist from a similarly rural background, who nurtures the desire to become a professional singer. Putting her career with a fairly popular band (and her passionate romance with one of its former members) firmly behind her, she boards the same train to Tokyo as Nana Komatsu. Through a fateful encounter in their journey toward the metropolis, the young women with the same given name are brought together, sparking a chain of events which eventually result in them sharing an apartment. As their friendship deepens, the two attempt to support each other through thick and thin, their deeply intertwined lives filled with romance, music, challenges, and heartbreaks that will ultimately test their seemingly unbreakable bond. [Written by MAL Rewrite]

The Evil Forces of Dark Joker are closing in on our planet after having destroyed the beautiful planet of Queen Earth. Now, 10 year old Moriya Ririka, with the help of her childhood friend Seiya and the mysterious Kanon, must transform into the Nurse Angel and find the elusive Flower of Life, the only way to defeat the evil forces. The Flower of Life, that once bloomed all over the Earth, is where no one thought it ever would be. And Ririka must make the hardest decision of her life in order to acquire it and rid the universe of evil once and for all. (Source: ANN)

Naho Takamiya's first day of her sophomore year of high school is off to an uneasy start. After waking up late, she receives a strange letter addressed to her. However, the letter is from herself—10 years in the future! At first, Naho is skeptical of the note; yet, after witnessing several events described to take place, she realizes the letter really is from her 26-year-old self. The note details that Naho's future life is filled with regrets, and she hopes that her younger self can correct the mistakes that were made in the past. The letter also warns her to keep a close eye on the new transfer student, Kakeru Naruse. Naho must be especially careful in making decisions involving him, as Kakeru is not around in the future. With the letter as her guide, Naho now has the power to protect Kakeru before she comes to regret it once more. [Written by MAL Rewrite]