An artificial island in Tokyo Bay—Kyokutou Houreigai Tokubetsu Chiku (Far East Special District), commonly known as the 24-ku (24th Ward). Childhood friends Ran, Kouki, and Shuuta, who were born and raised there, have different family backgrounds, hobbies, and personalities, but always hung out together. However, their relationship changes drastically in the wake of a certain incident. At the first anniversary memorial of the incident, the three friends happen to meet again and their phones begin to ring simultaneously. The phone call is from a supposedly dead friend, urging them to "choose the future." The three will try to protect their beloved 24th Ward and the future of its people in their own ways.

Since their days as students, Tsukasa Jinguuji has had incredible luck with women due to his good looks; Hinata Tachibana has had almost none, overshadowed by Jinguuji's brilliance. However, while Jinguuji has never shown interest in the opposite sex, Tachibana is always desperate for a girlfriend. Despite their polar differences, they continue to be best friends even in their thirties as salarymen. One night, the two are returning home from a mixer where Jinguuji was the center of attention as usual. In his drunken rambles, a frustrated Tachibana inadvertently wishes to become a beautiful girl with irresistible charm. As if the heavens were listening, a goddess suddenly shows herself before Jinguuji and Tachibana, transporting them to another world to defeat the Demon Lord and simultaneously granting Tachibana's desire. Tachibana—now in the body of an impossibly perfect woman—has become so attractive that even Jinguuji is captivated. Moreover, Tachibana grows aware of Jinguuji's stunning appearance, finally understanding his popularity. Before they fall in love with each other, the duo must complete their mission or risk remaining prisoners to their infatuations forever.

Middle school students Nishikata and Takagi sit next to each other in class. Takagi enjoys teasing Nishikata with embarrassing pranks and jokes. In response, Nishikata creates plans to get his revenge, but he fails when she identifies his weaknesses and capitalizes on them. In some rare instances where Takagi loses the challenge, Nishikata does not feel like he really won. The setting is based on the town of Tonoshō in the Kagawa Prefecture

In nineteenth-century France, humans and vampires coexist. The young vampire Noé is traveling to Paris in search of The Book of Vanitas, which is said to be capable of unleashing a curse upon all vampires. On an airship, he finds himself embroiled in a strange incident. It is Vanitas, a human calling himself a vampire expert, who appears before Noé in the ensuing chaos. In Vanitas’s hands is the very book that Noé has been searching for: The Book of Vanitas… Following this encounter, the curtain is set to rise on this tale of vampires, curses, and salvation…