As with both the Advanced Generation and Diamond & Pearl series before it, the Best Wishes! series begins with only Satoshi, headed off to the Isshu region, located far away from Kanto, Johto, Houen, and Sinnoh, with his Pikachu. After he meets up with the new trainer and rival Shooty and the region's Professor Araragi, he gains traveling companions in Iris, a girl from a town known for its Dragon Pokémon, and Dent, Pokémon Connoisseur and the Grass Pokémon specialist of the three Sanyou City Gym Leaders.

Unaired episode included with volume 3 of the Blu-ray release.

At the Penguin Village, the dinosaurs styled monster named Dodongadon appeared. But he was small as Arale and did not have strong power. Arale defeat him very easily, and Dodongadon called his mother Mamangadon. She was huge and had a big power. How Arale can defeat this big monster? (Source: Official Website)

Kabuto is a tengu who has to save a princess from fortress which is full of monster-mecha hybrids in an alternate reality of feudal Japan.