In a world of magic and monsters, Krylancelo Finrandi and his foster sister Azalie Cait-Sith were once promising students of sorcery, prodigies at the famous Tower of Fangs. But an experiment gone horribly wrong warps Azalie's appearance, trapping her in the form of a dragon. Elders at the Tower—more interested in preserving their reputation rather than their students' lives—drive off the transformed Azalie and cover up the incident. Outraged, Krylancelo strikes out on his own, taking the new name of "Orphen" and vowing to return Azalie to her normal state. Five years later, Orphen's quest has stalled. A chance encounter brings him face to face with Azalie again, but he still has no way to restore her body. And with a hostile group of sorcerers hunting her down, he may be running out of time. The past and present collide as Orphen tries to find how to save Azalie from their former teachers and friends.

The story of Sanzo and his three companions in their quest to the west, to stop the resurrection of Gyuumao. On the way they are fighting youkai, getting into trouble and helping the townspeople.

A devil-girl with the face of an angel and a heart of gold, blond Betty falls in love with an earthbound gangster, Danpei Kimogawa, when they meet in a rainstorm. They end up living together in a Tokyo highrise apartment, though Danpei has trouble coping with his new witch and demon in-laws dropping in at inopportune moments. Betty has actually been sent to the human world on a mission to defeat the demon Lutan. While Betty continues her task, her skeletal grandmother sends nubile nymphs to tempt Danpei and see if he is suitable husband material.

"First muscle training animation ever," a 16-year-old girl named Hinako leads exercises in push-ups, sit-ups, and squats. Hinako was once a human, but she was turned into an anime character when she was a second-year middle-school student.