In the future, Utopia has finally been achieved thanks to medical nanotechnology and a powerful ethic of social welfare and mutual consideration. This perfect world isn't that perfect though, and three young girls stand up to totalitarian kindness and super-medicine by attempting suicide via starvation. It doesn't work, but one of the girls—Tuan Kirie—grows up to be a member of the World Health Organization. As a crisis threatens the harmony of the new world, Tuan rediscovers another member of her suicide pact, and together they must help save the planet...from itself.

Hiroko Matsukata is a woman who works for a magazine company. She puts all she has into her work, and is known as a strong, straight-forward working girl, who can at will turn herself into Hataraki man (working man) mode. Despite Hiroko's success at work, her life lacks romance. Even though a hard worker, she'd leave early anytime to go on a date. Too bad her boyfriend is even bigger a workaholic than Hiroko.

The series is set in the distant future in which the Earth is split in two. The southern hemisphere is placed in another dimension while the inhabitants of the northern hemisphere are able to morph into beast-like humanoids. Eventually the humans of the southern hemisphere, led by Uranus, attack the Beasts. The Three Beasts, Wan Derbard (Wan Dabadadatta) of the Tiger Tribe, Bud Mint (Baado Mint) of the Bird Tribe, and Mei Mer (Mei Mah) of the Mermaid Tribe, are taken prisoner along with Mei Mer's companion Tuttle Millen (Mekka Mannen, also of the Mermaid tribe), but manage to escape thanks to a little girl named Yuuni Charm Password. Together they seek Gaia, which they believe to be a fabulous treasure, but they are pursued by Uranus's minions : V-Darn the vicious mage-knight, V-Sion the warrior woman and Akumako, V-Darn's sadistic imp-like partner.

Samatarou is not just an average high-school boy, the truth is that he is the son of a god, his mother is a goddess and his sisters are candidates to become goddesses. They are living in the human world, because they want their boy to learn about the human customs and the habits of the creatures that they are protecting, so that in this way Samatarou will become a better god. Tenko is a angel assigned to look after Samatarou. She's born the same day, same year as Samatarou and have been close friends ever since. Life seems normal but things start to change with the appearance of a transfer student named Kumiko. Samatarou falls in love with her and from now on, things will be a lot more different for him. His decision of making her fall in love with him without using his powers will put him in trouble.