The world of Yozakura Quartet is actually not one, but two worlds: one of humans, and one of youkai. Despite appearing mostly human, youkai may have animal like physical traits, along with a number of special abilities. Normally youkai are confined to their world, but some have found their way into the realm of humanity. As a symbol of peace, and a bridge between the two realms, a city was constructed within the protective barrier of seven magical trees, otherwise known as the Seven Pillars. This city of Sakurashin is home to both humans and youkai, with the peace between them maintained by the Hizumi Life Counseling Office. The director of this office is Akina Hiizumi, a teenager with the inherited family ability to perform “tuning,” which can send harmful youkai back to their world permanently. He is aided by a group of girls, including the town’s 16 year old youkai mayor, Hime Yarizakura, their town’s announcer and resident telepath, Ao Nanami, and Kotoha Isone, a half-youkai who can summon objects just by stating the object’s name. As new residents enter and mysterious events begin to take place, this quartet of protectors and their closest friends must continue to guard the city of Sakurashin, and maintain the fragile balance of peace between humans and youkai.

Eiri Kurahashi is a Japanese art student who works in an antique shop. His friends begin to notice a dramatic, and rather concerning, change in Eiri, as he becomes more absent-minded and his behavior completely changes. They quickly decide to blame their friend's troubles on a girl. They may be right, however, as Eiri has begun seeing a beautiful, doll-like girl trapped within an antique Venetian glass that his uncle bought in France. She seems to be living in a strange other world, contained entirely inside this glass, but her image refuses to leave Eiri's mind. His sketchbook becomes filled with her likeness, and he realizes he has become completely infatuated with this strange little girl. When he recognizes her in a portrait by the mysterious Italian artist, Marchello Orlando, he learns her name is Cossette d’Auvergne, and that she was tragically murdered along with the rest of her family. One night, as he closes up the shop, he hears a voice asking him not to leave. Finally making contact with the object of his obsession, he makes a deal that he doesn't fully understand. [Written by MAL Rewrite]

Specials included in the Blu-ray/DVD releases.

Sixteen-year-old Yuuki Hase finally finds the courage to speak to his crush and ask her if she wants to become friends. The object of his affection, Kaori Fujimiya, is a quiet and reserved girl who cuts herself off from everyone and does not spare him the same blunt rejection she gives everybody else. Some time after, Yuuki finds her eating lunch on the roof where she secludes herself during break. He decides to start meeting with Kaori every day in the hopes of beginning to understand her better. The more time they spend together, the more she begins to open up to him. However, nearing the end of the week, she starts to push him away once more. It is then revealed to him the reason for Kaori's cold front: at the end of the week, her memories of those close to her, excluding her family, are forgotten, as they are reset every Monday. The result of an accident in middle school, the once popular and kind Kaori is now unable to make friends in fear of hurting the people dear to her. Determined to become more than just one week friends, Yuuki asks her the exact same question each Monday: "Would you like to be friends?" Because he knows that deep down, Kaori wishes for that more than anything. [Written by MAL Rewrite]