After fanatically playing the VRMMO World Fantasy Online for almost a year, the shut-in yet relatively affluent fifteen-year-old Yuna receives a bear costume from the game's administrators. The outfit, while somewhat embarrassing to wear, turns out to have overpowered stats and effects that make her character significantly more powerful. After accepting the bear equipment, she finds herself transported to another in-game world that prevents her from returning to reality. Confused and unable to log out, Yuna sets out to explore this new environment. She rescues a girl named Fina from wild wolves, who then guides her to the city of Crimonia. With her eccentric bear attire, however, Yuna stands out wherever she goes, and alongside her boosted fighting prowess, her reputation quickly rises—to the point that people give her the nickname "Bloody Bear." Undeterred by this change in her life, Yuna decides to take on the role of an adventurer and fully enjoy herself in her new world.

Despite having a good reputation as one of the most seasoned guards in the local guild of Mebuki, Kikuru Madan believes he has been wasting his youth and hopes to spend the rest of it like any other person. However, his conscience prevents him from retiring at present, as he worries about the guild's future without him. Coincidentally—as if to help him find his successor—the guild's receptionist, Enome, assigns Kikuru four fresh recruits: the energetic beastwoman Hitamu "Hitamuki" Kyan, the prodigy Maidena Ange, the laid-back Toxico Dannar, and the stalwart Hanabata Nohkins. Although each of them possesses significant talents, they also display characteristics that detract from their potential—including Hitamu's extreme clumsiness and Hanabata's unintentional perverseness. As if there was not enough to deal with, the monsters outside Mebuki's walls start exhibiting odd behavior by targeting women salaciously, causing the party endless problems in more ways than one. Nevertheless, Kikuru is committed to retiring early; to achieve his goal, the guidance he gives the trainees will be absolutely essential.

From her hometown to her daily life on Kurken Island, everything surrounding Reisalin "Ryza" Stout is painfully ordinary. Despite being the daughter of a hardworking farmer, she would rather go on pretend adventures as she explores almost every corner of the island. However, the fact that it is against the local customs to venture off Kurken Island irritates her to no end. One day, wishing for something interesting to finally happen in her life, Ryza escapes on a boat with her two good friends: the bookworm Tao Mongarten and the aspiring warrior Lent Marslink. Arriving at a nearby forest, the trio stumbles into Klaudia Valentz, the daughter of a visiting merchant who also wandered off into the woods. As the naive and underprepared group ventures further, they run into dangerous monsters. Thankfully, they are rescued by the alchemist Empel Vollmer and his skilled bodyguard Lila Decyrus. This fateful encounter will lead Ryza to the key that will change her life forever—the creative and wonderful world of alchemy.

The Yuzuki family, which consists of four brothers, lost their parents two years ago. Hayato, the eldest son, is a hard worker and the pillar of the family. Mikoto, the second son, is calm and collected, but he has a soft spot for his younger brother Minato, whom he adores and thinks is cute. Minato, the third son, is energetic and adores his brothers, but he is clumsy and awkward. Gakuto, the fourth son, is a studious and mature first-grader who is often referred to as a "wise man." The manga depicts the four brothers' daily lives as they navigate their family, school, and community.