The anime follows the daily life of PuniRunes—mysterious creatures who love to be coddled—and Yuka, a fourth-grade girl who loves soft, squishy things.

A decade ago, 450-year-old vampire Ranmaru Mori was saved from the brink of death by Rihito Tatsuno, a young and innocent boy. Ever since then, Ranmaru has been working at the Tatsuno family's bathhouse with a secret: he wants a taste of Rihito's virgin blood as soon as he turns 18. However, his plan is threatened when Rihito falls in love with a girl on his first day of high school. Jealous and scared that Rihito's pureness will be ruined, Ranmaru begins to lurk in the shadows to protect him from any harm. During his operation, the vampire must keep his real identity hidden and make sure his target's virginity remains unsullied.

Robotic invaders wiped out all life, but Renge fights to survive using her powers. With no memories, she roams the city until she meets five other young women, each with unique abilities. Together, they make the most of their lives, cooking delicious meals between battles with mechanical monstrosities. As they uncover the secrets of their powers and pasts, they find strength in their friendship.