At a young age, Nitaroh is stricken with an illness that leaves him blind. He inherits the shamisen once used by his mother and is taught its basics by a blind traveling shamisen player. In time, with the help of friends old and new, he walks the paths that leads to his ultimate fate—that of founder of the Tsugaru style of shamisen playing.

Professor Layton's daughter, Katrielle Layton, runs the Layton Detective Agency together with the talking dog Sherl and her assistant Ernest, and solves strange cases that happen everyday in London. Originally, she started the job with the purpose of finding her father, Hershel Layton, who had disappeared suddenly, but her incredible ability to solve puzzles made her well-known and she receives numerous requests.

Daigo Asahina is Medaka Gumi #2's/Me Gumi's new rookie firefighter, and already he's done crazy things, like throwing people off of a rooftop to save them from an explosion. He had good intentions, but his deeds are starting to hurt the company's reputation. At Sengoku City's Concert Hall, a fire breaks, and the some Emergency Rescue Squad needs rescuing. Daigo will do all he can to keep his promise: Not to let anyone die on the job.