Millie Nocturne has one great goal in life: to be the best in the universe - at absolutely everything! But when she tries her hand at being the "best detective," she ends up an unwilling partner with two people who will change her life forever: Kane Blueriver, the psi-blade-wielding master of the starship Swordbreaker, and Canal, the smart-mouthed holographic image of the ship's computer. Join this unlikely trio on their adventures as they hurtle through space facing off against intergalactic crime lords, rogue starships, and hijackers dressed as chickens... and that's just the tip of the asteroid!

In ancient times, some witches married their familiars, who had taken human form, giving birth to a lineage of ogres. One such ogre is Morihito Otogi, who while appearing completely human, still retains the inhuman strength of his bloodline. Nico Wakatsuki is a young witch and Morihito's childhood friend, but as part of her education, she had to go to the Witches' Holy Land to train and part ways with Morihito . Years later, just before Morihito's first year of high school, Nico returns home with one goal in mind: to claim him as her familiar. While most witches choose a cat or a bat, Nico has her heart set on Morihito in more ways than one. Although seemingly oblivious to her true feelings, Morihito and Nico end up living together under the same roof with both of Morihito's parents elsewhere. While reluctant at first, Morihito accepts his new role, determined to help Nico seamlessly fit back in with human society and protect her from fated disaster.

During Japan's feudal era, there was a war between two ninja clans: the Byakuro and the Kabusu. One night, the Kabusu staged a fierce attack on the Byakuro castle in hopes of kidnapping the clan's infant princess. Their mission was foiled when a loyal ninja of the Byakuro flees the attack with the princess and disappears, eventually raising her to be a ninja. Several years later, six ninja trainees are given a mission to infiltrate the Kabusu-occupied Byakuro castle and retrieve a sacred scroll to complete their training. But their skills are put to the test when they encounter three members of the Kabusu, who use dark sorcery in an attempt to once again capture the princess - who happens to be one of the trainees.

After a strategic maneuver, Senkuu Ishigami's team stalls Dr. Xeno's more scientifically advanced forces. A ceasefire between the two factions allows for the establishment of Corn City in North America, a hope for a future thriving population. Meanwhile, Senkuu and some of his teammates rush toward the Amazon in South America—the epicenter of the petrification beam's impact—to create Superalloy City and progress their spaceship project. With dangerous enemies still pursuing Senkuu and his companions, it is a race against time to reach the heart of the dense Amazon. As unexpected allies and scientific creations further fuel this leg of their journey, Senkuu is closer than ever to finally uncovering the mystery behind the petrification phenomenon.