In ancient times, some witches married their familiars, who had taken human form, giving birth to a lineage of ogres. One such ogre is Morihito Otogi, who while appearing completely human, still retains the inhuman strength of his bloodline. Nico Wakatsuki is a young witch and Morihito's childhood friend, but as part of her education, she had to go to the Witches' Holy Land to train and part ways with Morihito . Years later, just before Morihito's first year of high school, Nico returns home with one goal in mind: to claim him as her familiar. While most witches choose a cat or a bat, Nico has her heart set on Morihito in more ways than one. Although seemingly oblivious to her true feelings, Morihito and Nico end up living together under the same roof with both of Morihito's parents elsewhere. While reluctant at first, Morihito accepts his new role, determined to help Nico seamlessly fit back in with human society and protect her from fated disaster.

Marin is a typical junior high school girl with a sunny disposition and a loving adoptive family. Her life takes a drastic change when a mysterious mirage is seen in the sky above the entire earth. Killer androids called Monomakia descend to earth from the formation in the sky called Brigadoon and begin to hunt down little Marin. She discovers a blue bottle in a shrine as she seeks escape and from the bottle comes a protector, a sword carrying gun slinging alien called Melan Blue, together they must save the earth and deal with family crisis, school prejudice and the police and come to an understanding of Marins past and Melans unexplained mission, as well as learn to trust each other. Set in 1969 Japan with a colorful cast of friends and enemies.

After a strategic maneuver, Senkuu Ishigami's team stalls Dr. Xeno's more scientifically advanced forces. A ceasefire between the two factions allows for the establishment of Corn City in North America, a hope for a future thriving population. Meanwhile, Senkuu and some of his teammates rush toward the Amazon in South America—the epicenter of the petrification beam's impact—to create Superalloy City and progress their spaceship project. With dangerous enemies still pursuing Senkuu and his companions, it is a race against time to reach the heart of the dense Amazon. As unexpected allies and scientific creations further fuel this leg of their journey, Senkuu is closer than ever to finally uncovering the mystery behind the petrification phenomenon.

While the mission to exorcise Jin "Jiji" Enjouji's family home is underway, things are not going as expected. Momo Ayase narrowly evades an attempted abduction while Ken "Okarun" Takakura and Jiji are ambushed by the Kitou family—the unsettling landlords of the cursed estate. The trio's efforts threaten the foundation of this enigmatic town shrouded in legends and mysteries. As Momo, Okarun, and Jiji are drawn deeper into the maze of folklore and supernatural entities, they must each utilize their unique powers if they want to survive and unravel the secrets of the uncanny town.