The plot of Open Your Mind follows the extraterrestrial origin of life, coming from outerspace as six deities (Intermission act), evolving into water (Sho-ho) then emerging to the air (Hyakkin) and to the ground (Ku-nu). Each one of these creatures rules one of the six elements of the godai philosophy, i.e. Earth, Water, Fire, Wind (referred to as kaze in the Hyakkin chant), Sky and Consciousness (referred to as "Awakening" in the movie's title).

Several short animated mini-stories based on the short stories and four-panel manga of Keiko Fukuyama, including My Father the Mouse, The Rabbit Brothers, Summer Secret, The Mysterious Fairy, How Very Strange, and Kuro.

Gou has woved to find the legendary treasure of Salamander. Searching for it he meets Ren, a fairy, who is looking for the four treasures of Heart. Gou's childhood friend Mari is frustrated with Gou running after treasures, but befriends with another fairy Rin. Gou and Ren's treasure hunt messes with a secret project led by Mari's father. It turns out Salamander isn't what Gou thought it was in the first place...

In his past life, although too weak to protect his home when it counted, out of grave determination Nie Li became the strongest Demon Spiritist and stood at the pinnacle of the martial world. However, he lost his life during the battle with the Sage Emperor and six deity-ranked beasts. His soul was then brought back to when he was still 13 years old. Although he's the weakest in his class with the lowest talent, having only a red soul realm and a weak one at that, with the aid of the vast knowledge which he accumulated from his previous life, he decided to train faster than anyone could expect. He also decided to help those who died nobly in his previous life to train faster as well. He aims to protect the city from the coming future of being devastated by demon beasts and the previous fate of ending up destroyed. He aims to protect his lover, friends, family and fellow citizens who died in the beast assault or its aftermath. And he aims to destroy the so-called Sacred family who arrogantly abandoned their duty and betrayed the city in his past life.