Sightings of mysterious creatures known as "Hologram Ghosts" have been a popular topic on social networks for the past few years. According to the rumors, several people have fallen victim to these specters. Those fortunate to survive their encounters with the paranormal beings claim that they resembled glitched holograms. Hazakura Academy middle school student Hiro Amanokawa believes these sightings are merely an urban legend. However, as the incidents start to increase in frequency, he is reminded of the day his father suddenly vanished, with strange digital watches serving as the only relics of his disappearance. Much like the other sightings, what happened to Hiro's father cannot be explained by conventional logic. One day, when a fellow student in the academy is attacked by a Hologram Ghost, Hiro and his friend Kiyoshirou Higashimitarai decide to look into the matter. Little does Hiro know that this investigation will be their first step toward discovering a dangerous world previously unknown to mankind.

Mitsuha Yamano could not have had it worse. After failing to enter her university of choice and losing her entire family in an accident, she finds herself plummeting off a cliff due to an especially fragile guardrail. Through what seems to be the only bit of the fortune left in her life, Mitsuha's firm unwillingness to die allows her to be transported to another world, where she ends up surviving. In this foreign land, Mitsuha wanders around for days before collapsing from exhaustion and being rescued by a little girl named Colette. Not long after, she finds herself in yet another life-threatening situation, and her indomitable will shines once more, granting her an audience with a divine cosmic being. The entity reveals to Mitsuha that she has acquired not only superhuman regeneration but also the ability to transport between worlds at will. Armed with this new information, Mitsuha brainstorms ways to utilize her newfound power to its full potential. Realizing that she can take goods from Earth and resell them to the other world at a higher price, she resolves to save up eighty thousand gold coins to be able to retire comfortably.

Since reincarnating into a new world, Ryouma Takebayashi has used his god-given graces to tame countless slimes and employ them to improve the lives of everyone around him. With the astonishing success of his laundry shop, Bamboo Forest, he is finally ready to take on new frontiers and open a branch in the neighboring city of Lenaf. Abiding by his promise with his dearest friend, Eliaria Jamil, Ryouma makes every day count, whether learning new techniques, forming connections, or even discovering more species of slime.

Despite being a handyman with a wide range of skills, Saitou is severely undervalued and underpaid. When he complains, his boss fires him, claiming that he is easily replaceable. As if his luck was not bad enough, a truck suddenly hits and kills Saitou on his way home. Surprisingly enough, Saitou does not die; instead, he is transported to another world. There, he meets a party composed of the female knight Raelza, the moonlight fairy Lafanpan, and the mage Morlock, who are all coincidentally looking to recruit a new member with a skill set like Saitou's. Throughout their time together, Saitou uses his expertise to assist his fellow party members and soon comes to receive the recognition he never thought was possible. However, Saitou's presence may just be the catalyst that will connect a diverse cast of people from different places, slowly uncovering the fate that could bring a great change to this world.