The Bitches Are Back!! In Daten City, a realm between heaven and hell, sinister spirits known as "Ghosts" prowl the streets, feeding on human desires and resentment. Yet, in the darkest moments, two figures emerge to obliterate these vengeful beings with a divine light beyond human understanding. Their names? Panty & Stocking! These fallen angel sisters have been tasked with purging the darkness engulfing the earth. But who are they, really? Are they truly messengers of God... or agents of the Devil?

A number of inexplicable phenomena have been plaguing the town of Domori. In order to protect the town's children, a new homeroom teacher known as "Nube" arrives. Normally gentle and a bit outgoing, Nube has a secret side: he is, in fact, the only psychic teacher in Japan. Rumor also has it his left hand is possessed by a demon!
Hell's messenger of justice is here to take on the school's seven mysteries, ghosts, and evil spirits attacking his students. This occultist action story starts now!

As the son of the late legendary actress Subaru Ayase, Yuu has had many expectations placed upon him after he transferred to Saika Academy, a highly prestigious school where students can hone their personal talents. However, in contrast to his mother, Yuu is completely talentless. Being seen as completely mediocre, he would have no chance of standing side by side with the three emperors of Saika Academy: the Mikadono sisters, Miwa, Nico, and Kazuki, who are each prodigies in shogi, martial arts, and performing arts, respectively. With Subaru's friend agreeing to take her son in, Yuu aims to fulfill his mother's last wish to him, which is to build a happy family, after never being able to form a proper mother-son relationship due to their difference in talent. As it turns out, his mother's friend is actually the father of the Mikadono sisters! Keeping his mother's wish in mind, Yuu aims to build familial bonds with the siblings. However, due to their extreme focus on their respective specializations, they show little interest in opening themselves up not only to him, but to each other as well. Nonetheless, Yuu strives to continuously support the three prodigies, as his kindness and care restores the bond between the sisters.

Nikola is just a village girl working at the inn...until the day dragons invade, and she meets Haga, a scholar of everything around him. He's a part of an elite society called "Seeker," created to address a series of maladies plaguing their usually peaceful world. But both Nikola and Haga have secrets they hide...ones that will change each other's very existence...