Megumin is a young and passionate wizard from the Crimson Demon Village, a remote community of mages with red eyes and a flair for the dramatic. She has devoted her life to mastering explosion magic, a powerful but impractical spell that leaves her drained of mana and unable to move for the rest of the day. Regardless, she refuses to learn any other skills. Along with her childhood friend and self-proclaimed rival, Yunyun, Megumin enrolls in the Red Prison: a prestigious academy for Crimson Demon magic users. There, she learns more about the secrets and history of her clan, as well as the threats and challenges they must face. As she polishes her power at the Red Prison with the help of her loyal familiar Chomusuke and her adorable little sister Komekko, Megumin aims to become the greatest explosion wizard of all time!

Sentenced to death, ninja Gabimaru the Hollow finds himself apathetic. After leading a blood-soaked life, Gabimaru believes he deserves to die. However, every attempt to execute him inexplicably fails. Finally, Sagiri Yamada Asaemon, a fledgling member of a famed executioner clan, is asked to take Gabimaru's life; yet Sagiri makes no move to kill him as requested. Insisting that Gabimaru will not die because of his love for his wife, Sagiri instead offers him the chance to obtain a full pardon for his crimes. If he can travel to the island of Shinsekyo and obtain the Elixir of Life—which supposedly grants immortality—and bring it back for the shogun, then his freedom will be assured. But of the many who have traveled to Shinsekyo in search of the mythical Elixir, not a single person has returned sound of mind, if at all. Though unaware of the numerous dangers ahead, Gabimaru decides to accept the offer—alongside ten other death row convicts—in hope that he and his wife may finally live in peace.

In the entertainment world, celebrities often show exaggerated versions of themselves to the public, concealing their true thoughts and struggles beneath elaborate lies. Fans buy into these fabrications, showering their idols with undying love and support, until something breaks the illusion. Sixteen-year-old rising star Ai Hoshino of pop idol group B Komachi has the world captivated; however, when she announces a hiatus due to health concerns, the news causes many to become worried. As a huge fan of Ai, gynecologist Gorou Amemiya cheers her on from his countryside medical practice, wishing he could meet her in person one day. His wish comes true when Ai shows up at his hospital—not sick, but pregnant with twins! While the doctor promises Ai to safely deliver her children, he wonders if this encounter with the idol will forever change the nature of his relationship with her.

Fifth season of .