By day, Romeo Maki is a respectable man who loves bringing gifts to the local orphanage, and Juliet is a newly employed nun working at said orphanage. However, by night, they are Masked Man M and Lady S, popular professional wrestlers. Kick-Heart tells the story of what happens when this dynamic pair meet in the ring, the only place where they can express their hidden desires.

A project was launched where scientists discovered a mysterious substance that can interface directly with the human brain. This substance, called "Exotic Matter (XM)," has existed since ancient times, influencing human minds and the progress of humanity. In the wake of this discovery, a battle of powerful nations and corporate giants has been unleashed. Organizations across the globe have embarked on a secret race to exploit XM. It represents both an opportunity and a threat to humanity. Two Factions seeks to control the XM. The Enlightened view XM's power as a gift that enhances human experience and discovery. The Resistance sees XM as a hostile takeover of the human mind, choosing technology as humanity's best path forward. XM, and the mystery behind it lie at the center of this battle for the fate of humanity. 2018—Now, a new struggle is about to unfold in Tokyo and across the globe. Dangerous and powerful forces seeking to exploit the potential of XM will collide. This groundbreaking project will mark the beginning of an epic augmented-reality experience combining the three elements of animation, location-based gaming, and the real world.

In the 21st century mankind was on the brink of destruction. Through genetic engineering however they eradicated such feelings as love and the desire for power. Since women are naturally less agressive than men, women to man ratio was set to 9:1. Now people are engineered to have skills that others view as being necessary. There is a giant ring that now orbits the earth, that sits there and relays information back to an alien race that sent it. Now a team of five women will try to eradicate the alien threat. (Source: ANN)

Throughout Shibuya, a series of murders dubbed the "New Generation Madness" gained widespread attention As these crimes gained infamy, they became a hot topic of discussion among the people of the area. Nonetheless, these "New Gen" murders do not capture the interest of Takumi Nishijou, a high school otaku who frequently experiences delusions and feels that he is constantly being watched. Having no concern for the real world, Takumi spends his time playing online games and watching anime. However, his ordinary life is disrupted when he receives a horrifying image of a man staked to a wall from a user named Shogun. After calming himself at an internet cafe, Takumi sees the exact same murder scene as the image portrayed happen right before his eyes, along with a pink-haired girl covered in blood calling out his name. Conflicted with the nature of reality, Takumi finds it difficult to judge where to place his trust as he gets caught up in the "New Gen" murders, believing that the murderer is out to get him.