To prepare for reincarnation in another world, Kelvin gives up select memories from his previous life in exchange for powerful abilities, additional skill points, and an S-class summoner title. As a bonus, the goddess facilitating his rebirth, Melfina, offers him a choice of any companion to give him a head start in his summoner role. Kelvin—who has fallen head over heels for Melfina at first sight—promptly chooses the deity, confident that his passionate feelings for her will resurface even without all of his memories. Kelvin embarks on his exciting new journey with Melfina as his guide. However, in order to summon his beloved goddess' physical form, he needs to acquire significant amounts of mana points—and the best way to accomplish this is to level up by fighting strong enemies and making contracts with even stronger companions.

World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class.

In the world of Remnant, humans and Faunus—human-animal hybrids—carry on their everyday lives despite the omnipresent threat of the monstrous Grimm. Dedicated Huntsmen and Huntresses battle Grimm with both customized weapons and their own "Semblances," unique abilities derived from the energy of one's soul. Some warriors also utilize a crystallized energy propellant, "Dust," to bestow their weapons with elemental properties. In this dangerous line of work, rigorous training is required to stay alive. To that end, each of Remnant's four Kingdoms have established schools to properly groom children holding aspirations of becoming licensed Huntsmen. At Beacon Academy in the Kingdom of Vale, a promising group of future Huntresses make their debut as Team RWBY. Ruby Rose, Weiss Schnee, Blake Belladonna, and Yang Xiao Long each come from different backgrounds and often butt heads as a result. However, when they cooperate, they are a formidable force who have even attracted the attention of Beacon's headmaster Professor Ozpin. Alongside fellow students such as those in Team JNPR, the young prodigy Ruby and her friends engage in adventures which pit them against an extremist Faunus group known as the White Fang. Every explosive encounter also brings them closer to the true villains orchestrating conflicts from the shadows.

The maid Lilith, hired to look after young Yuuri and his family's mansion, seems highly suspicious: she is too good to be true. Every dish she serves turns out to be delicious, the whole residence sparkles after she cleans it, and all the clothing has given off a pleasant scent since she started doing the laundry. Furthermore, her devilishly beautiful eyes only serve to heighten Yuuri's suspicions. Is Lilith perhaps a witch or a sorcerer? Yuuri cannot figure it out. But despite his misgivings, Yuuri has to live with Lilith as he tries to unravel the mystery behind her otherworldly charm.